Although itraconazole pulse therapy has proven to be more effective and acceptable than most of the other onychomycosis therapies, the ... long-term half-dose itraconazole pulse therapy is recommended . The efficacy of itraconazole pulse therapy was evaluated at 3, 6, 9, 12 and 15 months.The primary efficacy measures consisted of clinical cure (totally normal‐looking nails), mycological cure (negative fungal direct microscopy and negative fungal culture) and complete cure (consisting of a clinical cure and a mycological cure). If you are asked to take two doses a day, space the doses out by taking one of the doses in the morning and the other in the evening. For six cycles, despite the administration of half-dose for patients weighing no more than 55 kg, there was no statistical difference in the complete cure rate (P = .862).
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A total of 90 outpatients of our hospital with onychomycosis were randomised into three treatment groups: (1) standard itraconazole pulse therapy (200 mg twice per day, 1 week each month for three pulses); (2) long-term pulse therapy (200 mg twice per day, 1 week each month for six pulses); (3) low-dose and long-term pulse therapy (200 mg/d, 1 week per month for six pulses) and were followed up for 15 months.
Conclusions: Following pulse therapy with itraconazole (400 mg/d given for 1 week each month for 3 to 4 months), the drug has been detected in the distal ends of nails after the first pulse, and it has reached therapeutic concentrations with further therapy. Unable to load your collection due to an error It has been suggested that the feet should be kept clear and the sharing of nail clippers or nail files should be avoided, and footwear should be used in all public areas.Please check your email for instructions on resetting your password. If you do not receive an email within 10 minutes, your email address may not be registered, 1996 Jan;132(1):34-41. doi: 10.1001/archderm.132.1.34.J Am Acad Dermatol. Please enable it to take advantage of the complete set of features!
2001 Mar;44(3):485-91. doi: 10.1067/mjd.2001.110644.De Doncker P, Decroix J, Piérard GE, Roelant D, Woestenborghs R, Jacqmin P, Odds F, Heremans A, Dockx P, Roseeuw D.Arch Dermatol.
2001 Mar;44(3):479-84. doi: 10.1067/mjd.2001.110874.Doncker PD, Gupta AK, Marynissen G, Stoffels P, Heremans A.J Am Acad Dermatol. Wiley At the same time, the patients were advised to come to the hospital immediately if they felt abdominal pain, nausea, vomiting or had a change in urine colour. Long-term therapy is effective and safe for the treatment of toenail onychomycosis. Photographs were taken at each visit. This site needs JavaScript to work properly. Two patients experienced irregular menstrual periods. Unable to load your delegates due to an error It is recommended that two of these weekly courses are given for fingernail infections and three courses for toenail disease.In this study, outpatients with onychomycosis presenting to our hospital were treated with standard itraconazole pulse therapy (twice per day, for three pulses), long‐term therapy (twice per day, for six pulses,) or low‐dose and long‐term therapy (once per day, for six pulses) and followed up for 15 months to evaluate the treatment results.A total of 90 patients were included in this study (40 men; 50 women; 18‐70 years old; mean age of 38) were recruited from the Shanghai Tenth People's Hospital, Tongji University School of Medicine from December 2014 to October 2015. Group 2 received a monthly week-long pulse-therapy dose (500 mg per day for 7 days a month, for 4 months) and group 3 received a 500 mg/day dose for 7 days every 3 months, totaling four treatments.
Iatroconazole is distributed in the breast milk. Nine patients (four for three cycles and five for six cycles) experienced a transient increase in conjugated bilirubin, which all returned to the normal range 1 month later.
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There were no statistical differences regarding the effectiveness or side effects between the groups. The patients' adverse reactions, including gastrointestinal disturbances, skin reactions, and headaches, their duration, extent and prognosis were recorded in detail.The analysis was performed using descriptive statistical methods. To evaluate the efficacy and safety of different cycles of itraconazole pulse therapy, determine the optimal dosage and number of cycles for onychomycosis.
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